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Applied Biosystems, MDS Sciex discover biomarkers to develop treatments for age-related diseases
By Lisa Kerner
Charlotte, N.C., Aug. 23 - Applied Biosystems and its joint venture partner, MDS Sciex, said researchers discovered a panel of numerous unique candidate biomarkers with the potential to help develop more effective diagnostic tests and treatments for Alzheimer's disease, Parkinson's disease and Dementia with Lewy Bodies - three age-related diseases that affect more than 7 million people in the United States.
The spinal-based protein study on neurodegenerative diseases was published in the August issue of The Journal of Alzheimer's Disease.
Applied Biosystems said the study, the first of its kind, simultaneously compared candidate biomarkers in the three diseases using iTRAQ reagent labeling technology to identify and quantify biomarkers.
Researchers identified about 1,500 proteins in the human cerebral spinal fluid proteome to date.
"The results of this research may be a catalyst to using protein biomarkers to slow down the rising tide of devastating neurodegenerative diseases," lead study author Jing Zhang said in a company news release.
"Not only are these discoveries a beacon of hope for those people genetically susceptible to suffering from these diseases, but identifying panels of biomarkers could also potentially be used someday in the diagnosis and monitoring of these diseases."
Applied Biosystems, an Applera Corp. business based in Foster City, Calif., develops instrument-based systems, consumables, software and services for new pharmaceuticals.
MDS Sciex is the scientific instrumentation and technology solutions division of Toronto-based MDS Inc.
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