Add to balance / Manage account | User: | Log out |
Prospect News home > News index > List of issuers T > Headlines for Targeted Genetics Corp. > News item |
Targeted Genetics notes modest immune response in HIV vaccine trial; to release interim results
By Elaine Rigoli
Tampa, Fla., Aug. 30 - Targeted Genetics Corp. said that no safety concerns were identified during its phase 1 clinical trial of tgAAC09, an investigational HIV/AIDS vaccine candidate based on recombinant adeno-associated virus vector serotype 2, and that the vaccine was well tolerated.
Additionally, modest immune responses were observed in a subset of the volunteers receiving a single administration of the highest dose of the vaccine.
The company said this phase 1 trial is the first to test a recombinant adeno-associated virus vector-based vaccine and is primarily designed to evaluate safety and tolerability of the vaccine at escalating dose levels. The study is also designed to evaluate immune responses following vaccination.
Further studies are planned to determine the clinical relevance of the modest immune responses so far observed, the company noted in a news release. Meanwhile, the company plans to release interim results from the phase 1 trial.
The trial is being conducted in collaboration with the International AIDS Vaccine Initiative and enrolled healthy volunteers who are not infected with HIV. The trial has concluded in Belgium and Germany and is ongoing in India.
A second clinical trial of tgAAC09 is ongoing in South Africa, Uganda and Zambia to evaluate a higher dose of the vaccine and to systematically evaluate the utility and optimal timing of boost vaccination.
Targeted Genetics is a biotechnology company located in Seattle.
© 2015 Prospect News.
All content on this website is protected by copyright law in the U.S. and elsewhere.
For the use of the person downloading only.
Redistribution and copying are prohibited by law without written permission in advance from Prospect News.
Redistribution or copying includes e-mailing, printing multiple copies or any other form of reproduction.