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Idera begins phase 1/2 oncology trial of HYB2055
By Jennifer Chiou
New York, Oct. 26 - Idera Pharmaceuticals, Inc. said it initiated a phase 1/2 clinical trial of HYB2055 with chemotherapy agents gemcitabine and carboplatin.
HYB2055 or IMOxine, Idera's lead toll-like receptor 9 agonist for cancer, is based on the company's Immune Modulatory Oligonucleotide (IMO) technology.
The trial is a two-phase, open-label dose escalation study of safety and efficacy.
"Our preclinical studies in animal tumor models demonstrated a significant added benefit from IMO treatment combined with several standard chemotherapies," Tim Sullivan, vice president of development programs, said in news release.
"As a result, we have initiated the trial and are seeking to enroll 12 to 18 refractory solid tumor patients in the phase 1 portion of the trial.
"We plan to use the phase 1 data for dose selection for the subsequent phase 2 portion of the trial in the treatment of naive non-small cell lung cancer patients."
Gemcitabine or Gemzar is Eli Lilly and Co.'s chemotherapy drug.
Idera, a biotechnology company focused on the development and commercialization of immune therapies based on Toll-like receptors that control immune response modulation, is based in Cambridge, Mass.
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